Article
Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia.
Blood - 15 Jan 2007
Cox Charlotte V, Martin Hannah M, Kearns Pamela R, Virgo Paul, Evely Roger S, Blair Allison
Abstract excerpt
A significant proportion of children with T-cell acute lymphoblastic leukemia (T-ALL) continue to fail therapy. Consequently, characterization of the cells that proliferate to maintain the disease should provide valuable information on the most relevant therapeutic targets. We have used in vitro suspension culture (SC) and nonobese diabetic-severe combined immune deficient (NOD/SCID) mouse assays to...
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