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Article

CIITA is not associated with risk of developing rheumatoid arthritis.

Genes and immunity - 1 Apr 2011

Bronson P G, Ramsay P P, Seldin M F, Gregersen P K, Criswell L A, Barcellos L F

Abstract excerpt

The major histocompatibility complex (MHC) class II transactivator gene (CIITA) encodes an important transcription factor regulating genes required for human leukocyte antigen (HLA) class II MHC-restricted antigen presentation. MHC genes, particularly HLA class II, are strongly associated with risk of developing rheumatoid arthritis (RA). Given the strong biological relationship between CIITA and HLA class II...

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Identifiers

PMID: 21248776
DOI: 10.1038/gene.2010.67
PMCID: PMC3449225

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CIITA is not associated with risk of developing rheumatoid arthritis.PMID 21248776Read ↗

Interaction analysis between HLA-DRB1 shared epitope alleles and MHC class II transactivator CIITA gene with regard to risk of rheumatoid arthritis.Semantic proximity Read ↗

CIITA gene variants are associated with rheumatoid arthritis in Scandinavian populations.Semantic proximity Read ↗

CIITA gene polymorphism (rs3087456) in systemic lupus erythematosus and rheumatoid arthritis: A population-based cohort study.Semantic proximity Read ↗

Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans.Semantic proximity Read ↗

Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance.Semantic proximity Read ↗

The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus.Semantic proximity Read ↗

Analysis of CIITA encoding AIR-1 gene promoters in insulin-dependent diabetes mellitus and rheumatoid arthritis patients from the northeast of Italy: absence of sequence variability.Semantic proximity Read ↗

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Single nucleotide polymorphisms in the gene encoding the major histocompatibility complex class II transactivator (CIITA) in systemic lupus erythematosus.Semantic proximity Read ↗

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