CIITA gene polymorphism (rs3087456) in systemic lupus erythematosus and rheumatoid arthritis: A population-based cohort study.

doi:10.1111/iji.12548

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Article

CIITA gene polymorphism (rs3087456) in systemic lupus erythematosus and rheumatoid arthritis: A population-based cohort study.

International journal of immunogenetics - 1 Oct 2021

Lima Suelen Cristina, Gomes da Silva Isaura Isabelle Fonseca, Nascimento Denise de Queiroga, de Moura Ronald Rodrigues, Mesquita Matheus da Silva, Asano Nadja Maria Jorge, Fernandes Gisele Vagjel, Valente Lucila Maria, Rushansky Eliezer, Mariano Maria Helena Queiroz de Araújo, Xavier Ricardo Machado, Chies José Artur Bogo, Crovella Sergio, Sandrin-Garcia Paula

Abstract excerpt

Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are influenced by genetic variants in immune system HLA genes. The Class II Major Histocompatibility Complex Transactivator (CIITA) is an important co-activator of the HLA transcriptional complex; the single nucleotide variant (SNV) rs3087456 localized in the gene promoter region (-168 A/G) has been reported as able to modify its transcription...

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PMID: 34180145
DOI: 10.1111/iji.12548

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