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Article

A pathway for the transmission of allosteric signals in the ribosome through a network of RNA tertiary interactions.

Journal of molecular biology - 3 Feb 2006

Chan Yuen-Ling, Dresios John, Wool Ira G

Abstract excerpt

There are a large number of tertiary contacts between nucleotides in 23S rRNA, but which are of functional importance is not known. Disruption of one between A2662 in the sarcin/ricin loop (SRL) and A2531 in the peptidyl-transferase center (PTC) has adverse effects on cell growth and on the ability of ribosomes to catalyze some but not other partial reactions of elongation. A lethal A2662C mutation is suppressed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16359709
DOI: 10.1016/j.jmb.2005.11.037

Genes

SRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A pathway for the transmission of allosteric signals in the ribosome through a network of RNA tertiary interactions.PMID 16359709Read ↗

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