Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The phenotype of mutations of G2655 in the sarcin/ricin domain of 23 S ribosomal RNA.

Journal of molecular biology - 22 Jan 1999

Macbeth M R, Wool I G

Abstract excerpt

The sarcin/ricin domain (SRD) in Escherichia coli 23 S rRNA forms a part of the site for the association of the elongation factors with the ribosome and hence is critical for the binding of aminoacyl-tRNA and for translocation. The domain is also the site of action of the eponymous toxins which catalyze covalent modification of single nucleotides that inactivate the ribosome. The conformation of the conserved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Division
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Nucleic Acid Conformation

Share to Phenotype

Share to Plasmids

Source

Identifiers

PMID: 9918717
DOI: 10.1006/jmbi.1998.2388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The phenotype of mutations of G2655 in the sarcin/ricin domain of 23 S ribosomal RNA.PMID 9918717Read ↗

The phenotype of mutations of the base-pair C2658.G2663 that closes the tetraloop in the sarcin/ricin domain of Escherichia coli 23 S ribosomal RNA.Semantic proximity Read ↗

Biochemical evidence of translational infidelity and decreased peptidyltransferase activity by a sarcin/ricin domain mutation of yeast 25S rRNA.Semantic proximity Read ↗

Characterization of in vitro and in vivo mutations in non-conserved nucleotides in the ribosomal RNA recognition domain for the ribotoxins ricin and sarcin and the translation elongation factors.Semantic proximity Read ↗

Selection for intragenic suppressors of lethal 23S rRNA mutations in Escherichia coli identifies residues important for ribosome assembly and function.Semantic proximity Read ↗

A pathway for the transmission of allosteric signals in the ribosome through a network of RNA tertiary interactions.Semantic proximity Read ↗

Phenotypic heterogeneity of mutational changes at a conserved nucleotide in 16 S ribosomal RNA.Semantic proximity Read ↗

Affinity purification of ribosomes with a lethal G2655C mutation in 23 S rRNA that affects the translocation.Semantic proximity Read ↗

Functional role of the sarcin-ricin loop of the 23S rRNA in the elongation cycle of protein synthesis.Semantic proximity Read ↗

Mutational analysis of the ribosome.Semantic proximity Read ↗

Ribosomal RNA identity elements for recognition by ricin and by alpha-sarcin: mutation in the putative CG pair that closes a GAGA tetraloop.Semantic proximity Read ↗

Eukaryotic ribosomal RNA determinants of aminoglycoside resistance and their role in translational fidelity.Semantic proximity Read ↗

Deep mutational analysis of elongation factor eEF2 residues implicated in human disease to identify functionally important contacts with the ribosome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.