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Article

VapC20 of Mycobacterium tuberculosis cleaves the sarcin-ricin loop of 23S rRNA.

Nature communications - 1 Jan 2013

Winther Kristoffer S, Brodersen Ditlev E, Brown Alistair K, Gerdes Kenn

Abstract excerpt

The highly persistent and often lethal human pathogen, Mycobacterium tuberculosis contains at least 88 toxin-antitoxin genes. More than half of these encode VapC PIN domain endoribonucleases that inhibit cell growth by unknown mechanisms. Here we show that VapC20 of M. tuberculosis inhibits translation by cleavage of the Sarcin-Ricin loop (SRL) of 23S ribosomal RNA at the same position where Sarcin and other...

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Source

Identifiers

PMID: 24225902
DOI: 10.1038/ncomms3796

Genes

SRL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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