Article
Alteration in location of a conserved GTPase-associated center of the ribosome induced by mutagenesis influences the structure of peptidyltransferase center and activity of elongation factor G.
The Journal of biological chemistry - 9 Sept 2005
Sergiev Petr V, Lesnyak Dmitry V, Burakovsky Dmitry E, Kiparisov Sergey V, Leonov Andrei A, Bogdanov Alexey A, Brimacombe Richard, Dontsova Olga A
Abstract excerpt
Translocation catalyzed by elongation factor G occurs after the peptidyltransferase reaction on the large ribosomal subunit. Deacylated tRNA in the P-site stimulates multiple turnover GTPase activity of EF-G. We suggest that the allosteric signal from the peptidyltransferase center that activates EF-G may involve the alteration in the conformation of elongation factor binding center of the ribosome. The latter...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.