Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure and stability of variants of the sarcin-ricin loop of 28S rRNA: NMR studies of the prokaryotic SRL and a functional mutant.

RNA (New York, N.Y.) - 1 Oct 1998

Seggerson K, Moore P B

Abstract excerpt

NMR has been used to examine the conformational properties of two variants of the sarcin-ricin loop (SRL) from eukaryotic 28S rRNA, which is essential for elongation factor interactions with the ribosome: (1) its bacterial homologue, which lacks two of the bases that flank the conserved 12-nt sequence in the middle of the SRL, but which is functionally equivalent, and (2) a functionally active variant of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoribonucleases
Share to Escherichia coli
Share to Fungal Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrogen-Ion Concentration

Share to Mutation

Share to Nucleic Acid Conformation

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 9769095
DOI: 10.1017/s1355838298980773
PMCID: PMC1369693

Genes

SRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure and stability of variants of the sarcin-ricin loop of 28S rRNA: NMR studies of the prokaryotic SRL and a functional mutant.PMID 9769095Read ↗

NMR structure of the noncytotoxic alpha-sarcin mutant Delta(7-22): the importance of the native conformation of peripheral loops for activity.Semantic proximity Read ↗

The common and the distinctive features of the bulged-G motif based on a 1.04 A resolution RNA structure.Semantic proximity Read ↗

Ribosomal RNA identity elements for recognition by ricin and by alpha-sarcin: mutation in the putative CG pair that closes a GAGA tetraloop.Semantic proximity Read ↗

Functional role of the sarcin-ricin loop of the 23S rRNA in the elongation cycle of protein synthesis.Semantic proximity Read ↗

Functional role of the C-terminal tail of the archaeal ribosomal stalk in recruitment of two elongation factors to the sarcin/ricin loop of 23S rRNA.Semantic proximity Read ↗

The phenotype of mutations of G2655 in the sarcin/ricin domain of 23 S ribosomal RNA.Semantic proximity Read ↗

A pathway for the transmission of allosteric signals in the ribosome through a network of RNA tertiary interactions.Semantic proximity Read ↗

Characterization of in vitro and in vivo mutations in non-conserved nucleotides in the ribosomal RNA recognition domain for the ribotoxins ricin and sarcin and the translation elongation factors.Semantic proximity Read ↗

Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain.Semantic proximity Read ↗

The denatured state ensemble contains significant local and long-range structure under native conditions: analysis of the N-terminal domain of ribosomal protein L9.Semantic proximity Read ↗

Assignment of the L30-mRNA complex using selective isotopic labeling and RNA mutants.Semantic proximity Read ↗

Preparation of ribosomes for smFRET studies: A simplified approach.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.