The phenotype of mutations of the base-pair C2658.G2663 that closes the tetraloop in the sarcin/ricin domain of Escherichia coli 23 S ribosomal RNA.

doi:10.1006/jmbi.2000.3720

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Article

The phenotype of mutations of the base-pair C2658.G2663 that closes the tetraloop in the sarcin/ricin domain of Escherichia coli 23 S ribosomal RNA.

Journal of molecular biology - 19 May 2000

Chan Y L, Sitikov A S, Wool I G

Abstract excerpt

The sarcin/ricin domain (SRD) in Escherichia coli 23 S rRNA is a part of the site for the association of elongation factors with ribosomes and for that reason is critical for the binding of aminoacyl-tRNA and for translocation during the reiterative elongation reactions of protein synthesis. The SRD has a GAGA tetraloop that is shut off by a Watson-Crick C2658 x G2663 pair. The contribution of this pair to the...

Topics

Bacterial Proteins
Base Pairing
Base Sequence
Binding Sites
Endoribonucleases
Escherichia coli
Fungal Proteins
Genes, Lethal
Guanosine Triphosphate
Mutation
Oligoribonucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptide Elongation Factor G

Peptides

Phenotype

Plasmids

Promoter Regions, Genetic

Protein Binding

Protein Biosynthesis

Source

Open in PubMed

Identifiers

PMID: 10801349
DOI: 10.1006/jmbi.2000.3720

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