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Article

The molecular basis of brown, an old mouse mutation, and of an induced revertant to wild type.

Genetics - 1 Oct 1990

Zdarsky E, Favor J, Jackson I J

Abstract excerpt

The murine b locus encodes the tyrosinase related protein, TRP-1, a putative membrane-bound, copper-containing enzyme having about 40% amino acid identity with tyrosinase. The protein is essential for production of black rather than brown hair pigment. We show that skin of mutant brown mice contains the same amount of TRP-1 mRNA as wild type. On sequencing the coding region of the mutant mRNA we find four...

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Identifiers

PMID: 2245916
DOI: 10.1093/genetics/126.2.443
PMCID: PMC1204198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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