Article
The molecular basis of brown, an old mouse mutation, and of an induced revertant to wild type.
Genetics - 1 Oct 1990
Zdarsky E, Favor J, Jackson I J
Abstract excerpt
The murine b locus encodes the tyrosinase related protein, TRP-1, a putative membrane-bound, copper-containing enzyme having about 40% amino acid identity with tyrosinase. The protein is essential for production of black rather than brown hair pigment. We show that skin of mutant brown mice conta...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Hair Color
- Melanocytes
- Membrane Glycoproteins
- Mice
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- Oxidoreductases
- Phenotype
- Polymerase Chain Reaction