Article
Light is a dominant mouse mutation resulting in premature cell death.
Nature genetics - 1 Jun 1992
Johnson R, Jackson I J
Abstract excerpt
Light is a dominant mutant allele of the mouse brown locus which results in hairs pigmented only at their tips. The phenotype is due to premature melanocyte death. We have sequenced the tyrosinase-related protein-1 cDNA encoded at this locus from Light mice and found that it contains a single base alteration from wild-type, causing an Arg to Cys change in the protein. To further elucidate the mutant phenotype, we...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Death
- DNA
- DNA Mutational Analysis
- Genes, Dominant
- Melanocytes
- Membrane Glycoproteins
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data