Article
Light is a dominant mouse mutation resulting in premature cell death.
Nature genetics - 1 Jun 1992
Johnson R, Jackson I J
Abstract excerpt
Light is a dominant mutant allele of the mouse brown locus which results in hairs pigmented only at their tips. The phenotype is due to premature melanocyte death. We have sequenced the tyrosinase-related protein-1 cDNA encoded at this locus from Light mice and found that it contains a single base alteration from wild-type, causing an Arg to Cys change in the protein. To further elucidate the mutant phenotype, we...
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