Article
A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus.
The EMBO journal - 1 Feb 1992
Jackson I J, Chambers D M, Tsukamoto K, Copeland N G, Gilbert D J, Jenkins N A, Hearing V
Abstract excerpt
We have cloned and sequenced mouse cDNAs corresponding to a third member of a family of melanocyte-specific mRNAs, which encode tyrosinase and related proteins. This new member, tyrosinase-related protein-2 (TRP-2), has approximately 40% amino acid identity with the two other proteins in the family and has the same structural features including two copper binding sites, two cysteine-rich regions, a signal peptide...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- Crosses, Genetic
- DNA
- Epidermal Growth Factor
- Female
- Intramolecular Oxidoreductases
- Isomerases
- Male