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Article

Phenotypic rescue of mutant brown melanocytes by a retrovirus carrying a wild-type tyrosinase-related protein gene.

Development (Cambridge, England) - 1 Oct 1990

Bennett D C, Huszar D, Laipis P J, Jaenisch R, Jackson I J

Abstract excerpt

A mouse cDNA for the developmentally controlled, melanocyte-specific protein, tyrosinase-related protein 1 (TRP-1), was previously cloned and reported to show genetic linkage with the coat-colour locus brown (b) on mouse chromosome 4. The cDNA has been inserted into a retroviral vector derived fr...

Topics

Animals
Cells, Cultured
Genetic Vectors
Melanins
Melanocytes
Membrane Glycoproteins
Mice
Moloney murine leukemia virus
Oxidoreductases
Phenotype
Phorbol Esters
Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Source

Identifiers

PMID: 2133550
DOI: 10.1242/dev.110.2.471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2133550-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Phenotypic rescue of mutant brown melanocytes by a retrovirus carrying a wild-type tyrosinase-related protein gene.PMID 2133550Read ↗

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Coat color dilution in mice because of inactivation of the melanoma antigen MART-1.Semantic proximity Read ↗

Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice.Semantic proximity Read ↗

Characterization of TRP-1 mRNA levels in dominant and recessive mutations at the mouse brown (b) locus.Semantic proximity Read ↗

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