Article
Molecular genetics of the brown (b)-locus region of mouse chromosome 4. I. Origin and molecular mapping of radiation- and chemical-induced lethal brown deletions.
Genetics - 1 Jul 1994
Rinchik E M, Bell J A, Hunsicker P R, Friedman J M, Jackson I J, Russell L B
Abstract excerpt
Over a period of many years, germ-cell mutagenesis experiments using the mouse specific-locus test have generated numerous radiation- and chemical-induced alleles of the brown (b; Tyrp 1) locus in mouse chromosome 4. We describe here the origin, maintenance and initial molecular characterization...
Topics
- Alleles
- Animals
- Base Sequence
- Blotting, Southern
- Chromosome Mapping
- Crosses, Genetic
- DNA Mutational Analysis
- DNA Primers
- Deoxyribonucleases, Type II Site-Specific
- Female
- Gene Deletion
- Genes, Lethal
- Germ-Line Mutation
- Hair Color
- Male