Article
Molecular genetics of the brown (b)-locus region of mouse chromosome 4. I. Origin and molecular mapping of radiation- and chemical-induced lethal brown deletions.
Genetics - 1 Jul 1994
Rinchik E M, Bell J A, Hunsicker P R, Friedman J M, Jackson I J, Russell L B
Abstract excerpt
Over a period of many years, germ-cell mutagenesis experiments using the mouse specific-locus test have generated numerous radiation- and chemical-induced alleles of the brown (b; Tyrp 1) locus in mouse chromosome 4. We describe here the origin, maintenance and initial molecular characterization of 28 b mutations that are prenatally lethal when homozygous. Each of these mutations is deleted for Tyrp 1 sequences,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.