Article
Characterization of TRP-1 mRNA levels in dominant and recessive mutations at the mouse brown (b) locus.
Genetics - 1 Oct 1990
Jackson I J, Chambers D, Rinchik E M, Bennett D C
Abstract excerpt
The mouse brown locus encodes a putative membrane-bound metalloenzyme, tyrosinase-related protein-1 (TRP-1). We have examined the effect on mRNA expression of the locus of a number of mutant alleles. The common null mutant allele, brown, produces wild-type levels of TRP-1 mRNA, which is nonfunctional. Another recessive allele, cordovan-Harwell, has an intermediate, dark-brown phenotype and produces only very low...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Genes, Dominant
- Genes, Recessive
- Melanoma
- Membrane Glycoproteins
- Mice
- Molecular Sequence Data
- Mutation