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Article

A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo.

PLoS pathogens - 1 Jan 2012

Barrett Bradley S, Smith Diana S, Li Sam X, Guo Kejun, Hasenkrug Kim J, Santiago Mario L

Abstract excerpt

Tetherin is a membrane protein of unusual topology expressed from rodents to humans that accumulates enveloped virus particles on the surface of infected cells. However, whether this 'tethering' activity promotes or restricts retroviral spread during acute retrovirus infection in vivo is controversial. We report here the identification of a single nucleotide polymorphism in the Tetherin gene of NZW/LacJ (NZW)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22457621
DOI: 10.1371/journal.ppat.1002596
PMCID: PMC3310811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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