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Article

Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration

28 Oct 2009

Abstract excerpt

Tetherin is an IFN-inducible restriction factor that inhibits HIV-1 particle release in the absence of the HIV-1 countermeasure, viral protein U (Vpu). Although ubiquitous in HIV-1 and simian immunodeficiency viruses from chimpanzees, greater spot nosed monkeys, mustached monkeys, and Mona monkeys, other primate lentiviruses do not encode a Vpu protein. Here we demonstrate that SIV from Tantalus monkeys (SIVtan)...

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PMID: 19864625
DOI: 10.1073/pnas.0907075106

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Related research

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Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestrationPMID 19864625Read ↗

Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion.Semantic proximity Read ↗

Determinants of Tetherin Antagonism in the Transmembrane Domain of the Human Immunodeficiency Virus Type 1 Vpu ProteinSemantic proximity Read ↗

Species-Specific Activity of HIV-1 Vpu and Positive Selection of Tetherin Transmembrane Domain VariantsSemantic proximity Read ↗

Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated EndocytosisSemantic proximity Read ↗

Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2Semantic proximity Read ↗

Antagonism to and Intracellular Sequestration of Human Tetherin by the Human Immunodeficiency Virus Type 2 Envelope GlycoproteinSemantic proximity Read ↗

Antiviral Activity of the Interferon-Induced Cellular Protein BST-2/TetherinSemantic proximity Read ↗

Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity.Semantic proximity Read ↗

Tetherin Restricts Productive HIV-1 Cell-to-Cell TransmissionSemantic proximity Read ↗

Structural basis of tetherin function.Semantic proximity Read ↗

Tetherin/BST-2: Restriction Factor or Immunomodulator?Semantic proximity Read ↗

Antiviral Inhibition of Enveloped Virus Release by Tetherin/BST-2: Action and CounteractionSemantic proximity Read ↗

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