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Article

Molecular Evolution of the Primate Antiviral Restriction Factor Tetherin

30 Jul 2010

Abstract excerpt

BACKGROUND: Tetherin is a recently identified antiviral restriction factor that restricts HIV-1 particle release in the absence of the HIV-1 viral protein U (Vpu). It is reminiscent of APOBEC3G and TRIM5a that also antagonize HIV. APOBEC3G and TRIM5a have been demonstrated to evolve under pervasive positive selection throughout primate evolution, supporting the red-queen hypothesis. Therefore, one naturally...

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PMID: 20689591
DOI: 10.1371/journal.pone.0011904

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Molecular Evolution of the Primate Antiviral Restriction Factor TetherinPMID 20689591Read ↗

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