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Article

Inhibition of Lassa and Marburg Virus Production by Tetherin

18 Dec 2008

Abstract excerpt

Recently, tetherin has been identified as an effective cellular factor that prevents the release of human immunodeficiency virus type 1. Here, we show that the production of virus-like particles induced by viral matrix proteins of Lassa virus or Marburg virus was markedly inhibited by tetherin and that N-linked glycosylation of tetherin was dispensable for this antiviral activity. Our data also suggest that viral...

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Identifiers

PMID: 19091864
DOI: 10.1128/jvi.01607-08

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