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Article

Defects in the structure and expression of the genes for the T cell marker Rt6 in NZW and (NZB x NZW)F1 mice.

International immunology - 1 May 1995

Koch-Nolte F, Klein J, Hollmann C, Kühl M, Haag F, Gaskins H R, Leiter E, Thiele H G

Abstract excerpt

Rt6 is a T cell-restricted GPI-anchored membrane protein and a member of the family of mono(ADP-ribosyl)transferases. One of the two murine Rt6 genes is deleted in NZW mice. This finding is reminiscent of the deletion of one of the TCR beta genes in the same mouse strain and it is an intriguing possibility that these gene deletions arose by a common genetic mechanism. The Rt6 locus retained by the NZW mouse...

Topics

ADP Ribose Transferases
Amino Acid Sequence
Animals
Antigens, Differentiation, T-Lymphocyte
Base Sequence
Biomarkers
Female
Gene Expression Regulation
Lupus Erythematosus, Systemic
Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred NZB

Molecular Sequence Data

Mutation

Polymorphism, Restriction Fragment Length

RNA, Messenger

Species Specificity

T-Lymphocytes

Source

Identifiers

PMID: 7547715
DOI: 10.1093/intimm/7.5.883

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7547715-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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