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Article

Identification of Alternatively Translated Tetherin Isoforms with Differing Antiviral and Signaling Activities

27 Sept 2012

Abstract excerpt

Tetherin (BST-2/CD317/HM1.24) is an IFN induced transmembrane protein that restricts release of a broad range of enveloped viruses. Important features required for Tetherin activity and regulation reside within the cytoplasmic domain. Here we demonstrate that two isoforms, derived by alternative translation initiation from highly conserved methionine residues in the cytoplasmic domain, are produced in both...

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PMID: 23028328
DOI: 10.1371/journal.ppat.1002931

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