Transnuclear Mice with Predefined T Cell Receptor Specificities Against <i>Toxoplasma gondii</i> Obtained via SCNT

Abstract excerpt

Mice that are transgenic for rearranged antigen-specific T cell receptors (TCRs) are essential tools to study T cell development and function. Such TCRs are usually isolated from the relevant T cells after long-term culture, often after repeated antigen stimulation, which unavoidably skews the T cell population used. Random genomic integration of the TCR alpha and beta chain and expression from nonendogenous...

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