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Article

Nox4 B-loop creates an interface between the transmembrane and dehydrogenase domains.

The Journal of biological chemistry - 2 Apr 2010

Jackson Heather M, Kawahara Tsukasa, Nisimoto Yukio, Smith Susan M E, Lambeth J David

Abstract excerpt

By targeting redox-sensitive amino acids in signaling proteins, the NADPH oxidase (Nox) family of enzymes link reactive oxygen species to physiological processes. We previously analyzed the sequences of 107 Nox enzymes and identified conserved regions that are predicted to have important functions in Nox structure or activation. One such region is the cytosolic B-loop, which in Nox1-4 contains a conserved...

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Identifiers

PMID: 20139414
DOI: 10.1074/jbc.M109.084939
PMCID: PMC2856233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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