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Article

IFN-γ deficiency exacerbates experimental autoimmune neuritis in mice despite a mitigated systemic Th1 immune response.

Journal of neuroimmunology - 15 May 2012

Zhang Hong-Liang, Azimullah Sheikh, Zheng Xiang-Yu, Wang Xiao-Ke, Amir Naheed, Mensah-Brown Eric P, Al Shamsi Mariam, Shahin Allen, Press Rayomand, Zhu Jie, Adem Abdu

Abstract excerpt

Previous studies have shown that interferon-gamma (IFN-γ) is a proinflammatory cytokine that contributes to the pathogenesis of Guillain-Barré syndrome and its animal model, experimental autoimmune neuritis (EAN). Treatments with anti-IFN-γ antibodies improve clinical outcome in GBS patients and EAN animals and administration of IFN-γ markedly worsens EAN. Paradoxically, the mice deficient in IFN-γ remain...

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PMID: 22445739
DOI: 10.1016/j.jneuroim.2012.02.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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