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Article

Targeting IFN-λ Signaling Promotes Recovery from Central Nervous System Autoimmunity

18 Feb 2022

Abstract excerpt

Type III IFNs (IFNLs) are newly discovered cytokines, acting at epithelial and other barriers, that exert immunomodulatory functions in addition to their primary roles in antiviral defense. In this study, we define a role for IFNLs in maintaining autoreactive T cell effector function and limiting recovery in a murine model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis. Genetic or Ab-based...

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PMID: 35181638
DOI: 10.4049/jimmunol.2101041

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