Article

Targeting interferon- <sub>λ</sub> signaling promotes recovery from central nervous system autoimmunity

2021-08-17

Abstract excerpt

Type III interferons (IFNLs) are newly discovered cytokines, acting at epithelial and other barriers, that exert immunomodulatory functions in addition to their primary roles in antiviral defense. Here we define a role for IFNLs in maintaining autoreactive T cell effector function and limiting recovery in a murine model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE). Genetic or antibod...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b78d235-d455-5921-9d15-2f2b53677507
DOI: 10.1101/2021.08.17.456642

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting interferon- <sub>λ</sub> signaling promotes recovery from central nervous system autoimmunityDOI 10.1101/2021.08.17.456642Read

Targeting IFN-λ Signaling Promotes Recovery from Central Nervous System AutoimmunitySemantic proximity Read

Type III Interferons: Emerging Roles in AutoimmunitySemantic proximity Read

Endogenous, or therapeutically induced, type I interferon responses differentially modulate Th1/Th17‐mediated autoimmunity in the CNSSemantic proximity Read

The immunology of multiple sclerosis.Semantic proximity Read

Type I interferon pathway in CNS homeostasis and neurological disordersSemantic proximity Read

Current trends in multiple sclerosis research: an update on pathogenic concepts.Semantic proximity Read

CD8<sup>+</sup>T cells in multiple sclerosisSemantic proximity Read

Immunopathology of multiple sclerosis.Semantic proximity Read

New immunopathologic insights into multiple sclerosis.Semantic proximity Read

Uncovering immune characteristics of neurons in the context of multiple sclerosis and experimental autoimmune encephalomyelitisSemantic proximity Read

Initial Immunopathogenesis of Multiple Sclerosis: Innate Immune ResponseSemantic proximity Read

Which immune cells matter? The immunopathogenesis of multiple sclerosis.Semantic proximity Read