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Article

Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2009

Jäger Anneli, Dardalhon Valérie, Sobel Raymond A, Bettelli Estelle, Kuchroo Vijay K

Abstract excerpt

Experimental autoimmune encephalomyelitis (EAE) is a model of human multiple sclerosis induced by autoreactive Th cells that mediate tissue inflammation and demyelination in the CNS. Initially, IFN-gamma-producing Th1 cells and, more recently, IL-17-producing Th17 cells with specificity for myelin Ags have been implicated in EAE induction, but whether Th17 cells are encephalitogenic has been controversial....

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Source

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Identifiers

PMID: 19890056
DOI: 10.4049/jimmunol.0901906
PMCID: PMC2921715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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