Article
The impact of drug metabolizing enzyme polymorphisms on outcomes after antenatal corticosteroid use.
American journal of obstetrics and gynecology - 1 May 2012
Haas David M, Lehmann Amalia S, Skaar Todd, Philips Santosh, McCormick Catherine L, Beagle Kyle, Hebbring Scott J, Dantzer Jessica, Li Lang, Jung Jeesun
Abstract excerpt
OBJECTIVE: To determine the impact of maternal and fetal single nucleotide polymorphisms in key betamethasone pathways on neonatal outcomes. STUDY DESIGN: DNA was obtained from women given betamethasone and their infants. Samples were genotyped for 73 exploratory drug metabolism and glucocorticoid pathway single nucleotide polymorphisms. Clinical variables and neonatal outcomes were obtained. Logistic regression...
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