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DNA methylation signatures in human neonatal blood following maternal antenatal corticosteroid treatment

31 Mar 2022

Abstract excerpt

Antenatal corticosteroids (ACS) are used to treat women at risk of preterm birth to improve neonatal survival. Though affected children may be at long-term risk of neurobehavioural disorders, the driving mechanisms remain unknown. Animal studies have shown that ACS exposure can lead to overlapping changes in DNA methylation between the blood and the brain, identifying gene pathways for neurodevelopment, which...

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PMID: 35354798
DOI: 10.1038/s41398-022-01902-4

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