Article
Maternal Betamethasone for Prevention of Respiratory Distress Syndrome in Neonates: Population Pharmacokinetic and Pharmacodynamic Approach.
Clinical pharmacology and therapeutics - 1 Nov 2020
Foissac Frantz, Zheng Yi, Hirt Déborah, Lui Gabrielle, Bouazza Naïm, Ville Yves, Goffinet François, Rozenberg Patrick, Kayem Gilles, Mandelbrot Laurent, Benaboud Sihem, Jarreau Pierre-Henri, Tréluyer Jean-Marc
Abstract excerpt
Despite antenatal corticosteroids therapy, respiratory distress syndrome (RDS) is still a leading cause of neonatal morbidity and mortality in premature newborns. To date, the relationship between in utero fetal drug exposure and occurrence of RDS remains poorly evaluated. This study aims to describe the pharmacokinetics of betamethasone in pregnant women and to evaluate the transplacental drug transfer and...
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