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Article

Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor β gene due to activation of Wnt/β-catenin protein signaling.

The Journal of biological chemistry - 18 May 2012

O'Shea Patrick J, Kim Dong Wook, Logan John G, Davis Sean, Walker Robert L, Meltzer Paul S, Cheng Sheue-Yann, Williams Graham R

Abstract excerpt

Thyroid hormone (T(3)) acts in chondrocytes and bone-forming osteoblasts to control bone development and maintenance, but the signaling pathways mediating these effects are poorly understood. Thrb(PV/PV) mice have a severely impaired pituitary-thyroid axis and elevated thyroid hormone levels due to a dominant-negative mutant T(3) receptor (TRβ(PV)) that cannot bind T(3) and interferes with the actions of...

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Source

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Identifiers

PMID: 22442145
DOI: 10.1074/jbc.M111.311464
PMCID: PMC3366792

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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