Article
Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone.
Proceedings of the National Academy of Sciences of the United States of America - 21 Nov 2000
Kaneshige M, Kaneshige K, Zhu X, Dace A, Garrett L, Carter T A, Kazlauskaite R, Pankratz D G, Wynshaw-Boris A, Refetoff S, Weintraub B, Willingham M C, Barlow C, Cheng S
Abstract excerpt
Patients with mutations in the thyroid hormone receptor beta (TRbeta) gene manifest resistance to thyroid hormone (RTH), resulting in a constellation of variable phenotypic abnormalities. To understand the molecular basis underlying the action of mutant TRbeta in vivo, we generated mice with a targeted mutation in the TRbeta gene (TRbetaPV; PV, mutant thyroid hormone receptor kindred PV) by using homologous...
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