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Article

Regulation of β-Catenin by a Novel Nongenomic Action of Thyroid Hormone β Receptor

13 May 2008

Abstract excerpt

We previously created a knock-in mutant mouse harboring a dominantly negative mutant thyroid hormone receptor beta (TRbeta(PV/PV) mouse) that spontaneously develops a follicular thyroid carcinoma similar to human thyroid cancer. We found that beta-catenin, which plays a critical role in oncogenesis, was highly elevated in thyroid tumors of TRbeta(PV/PV) mice. We sought to understand the molecular basis underlying...

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PMID: 18474620
DOI: 10.1128/mcb.02192-07

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