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Article

The C-terminus of human nucleotide receptor P2X7 is critical for receptor oligomerization and N-linked glycosylation.

PloS one - 1 Jan 2013

Wickert Lisa E, Blanchette Joshua B, Waldschmidt Noelle V, Bertics Paul J, Denu John M, Denlinger Loren C, Lenertz Lisa Y

Abstract excerpt

BACKGROUND: The P2X7 receptor binds extracellular ATP to mediate numerous inflammatory responses and is considered a potential biomarker and therapeutic target for diverse inflammatory and neurological diseases. P2X7 contains many single nucleotide polymorphisms, including several mutations located within its intracellular C-terminal trafficking domain. Mutations within the trafficking domain result in attenuated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Purinergic P2X7

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Identifiers

PMID: 23691096
DOI: 10.1371/journal.pone.0063789
PMCID: PMC3653848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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