Article
Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence.
Science (New York, N.Y.) - 30 Nov 1990
Rauscher F J, Morris J F, Tournay O E, Cook D M, Curran T
Abstract excerpt
The Wilms' tumor locus (WTL) at 11p13 contains a gene that encodes a zinc finger-containing protein that has characteristics of a DNA-binding protein. However, binding of this protein to DNA in a sequence-specific manner has not been demonstrated. A synthetic gene was constructed that contained t...
Topics
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- Binding, Competitive
- Chromosomes, Human, Pair 11
- Consensus Sequence
- DNA
- DNA-Binding Proteins
- Early Growth Response Protein 1
- Escherichia coli
- Genes, Wilms Tumor
- Humans
- Immediate-Early Proteins
- Molecular Sequence Data
- Mutation
- Oligonucleotides
- Polymerase Chain Reaction
- Recombinant Proteins