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Article

Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence.

Science (New York, N.Y.) - 30 Nov 1990

Rauscher F J, Morris J F, Tournay O E, Cook D M, Curran T

Abstract excerpt

The Wilms' tumor locus (WTL) at 11p13 contains a gene that encodes a zinc finger-containing protein that has characteristics of a DNA-binding protein. However, binding of this protein to DNA in a sequence-specific manner has not been demonstrated. A synthetic gene was constructed that contained the zinc finger region, and the protein was expressed in Escherichia coli. The recombinant protein was used to identify...

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Identifiers

PMID: 2244209
DOI: 10.1126/science.2244209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence.PMID 2244209Read ↗

DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1.Semantic proximity Read ↗

Isolation and Characterization of a Novel Zinc-finger Protein with Transcriptional Repressor ActivitySemantic proximity Read ↗

RNA binding by the Wilms tumor suppressor zinc finger proteins.Semantic proximity Read ↗

Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.Semantic proximity Read ↗

Zinc finger point mutations within the WT1 gene in Wilms tumor patients.Semantic proximity Read ↗

An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.Semantic proximity Read ↗

Wilms' tumor 1 splice variants have opposite effects on the tumorigenicity of adenovirus-transformed baby-rat kidney cells.Semantic proximity Read ↗

Contribution of individual amino acids to the RNA binding activity of the Wilms' tumor suppressor protein WT1.Semantic proximity Read ↗

Functional characterization of WT1 binding sites within the human vitamin D receptor gene promoter.Semantic proximity Read ↗

Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.Semantic proximity Read ↗

Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains.Semantic proximity Read ↗

The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG.Semantic proximity Read ↗

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