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Article

The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG.

Oncogene - 1 Jun 1994

Funabiki T, Kreider B L, Ihle J N

Abstract excerpt

Inappropriate expression of the Evi-1 zinc finger gene is associated with myeloid leukemia and myelodysplastic syndromes in mice and humans and has been hypothesized to contribute to pathology by blocking myeloid differentiation. Evi-1 contains two domains of zinc fingers, an amino-terminal domai...

Topics

Animals
Base Sequence
Binding Sites
DNA
DNA-Binding Proteins
Leukemia, Myeloid
MDS1 and EVI1 Complex Locus Protein
Mice
Molecular Sequence Data
Mutation
Oncogenes
Proto-Oncogenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Structure-Activity Relationship

Transcription Factors

Zinc Fingers

Source

Identifiers

PMID: 8183551

Genes

CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8183551-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG.PMID 8183551Read ↗

Point Mutations in Two EVI1 Zn Fingers Abolish EVI1-GATA1 Interaction and Allow Erythroid Differentiation of Murine Bone Marrow CellsSemantic proximity Read ↗

<i>Evi9</i> Encodes a Novel Zinc Finger Protein That Physically Interacts with BCL6, a Known Human B-Cell Proto-Oncogene ProductSemantic proximity Read ↗

Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene.Semantic proximity Read ↗

EVI1 dysregulation: impact on biology and therapy of myeloid malignancies.Semantic proximity Read ↗

Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming gene activate transcription from the normal promoter.Semantic proximity Read ↗

A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF–induced myeloid differentiationSemantic proximity Read ↗

Zinc Finger Nucleases as tools to understand and treat human diseasesSemantic proximity Read ↗

EVI1 Impairs Myelopoiesis by Deregulation of PU.1 FunctionSemantic proximity Read ↗

Transcriptional regulation by the carboxyl terminus of c-Myb depends upon both the Myb DNA-binding domain and the DNA recognition site.Semantic proximity Read ↗

The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development.Semantic proximity Read ↗

Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemiaSemantic proximity Read ↗

A Krüppel-like factor 1 (KLF1) Mutation Associated with Severe Congenital Dyserythropoietic Anemia Alters Its DNA-Binding Specificity.Semantic proximity Read ↗

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