Article
Functional characterization of WT1 binding sites within the human vitamin D receptor gene promoter.
Physiological genomics - 21 Dec 2001
Lee T H, Pelletier J
Abstract excerpt
The Wilms' tumor suppressor gene, wt1, encodes a zinc finger transcription factor that can regulate gene expression. It plays an essential role in tumorigenesis, kidney differentiation, and urogenital development. To identify WT1 downstream targets, gene expression profiling was conducted using a cDNA array hybridization approach. We confirm herein that the human vitamin D receptor (VDR), a ligand-activated...
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