Disposed to distraction: genetic variation in the cholinergic system influences distractibility but not time-on-task effects.

doi:10.1162/jocn_a_00607

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Article

Disposed to distraction: genetic variation in the cholinergic system influences distractibility but not time-on-task effects.

Journal of cognitive neuroscience - 1 Sept 2014

Berry Anne S, Demeter Elise, Sabhapathy Surya, English Brett A, Blakely Randy D, Sarter Martin, Lustig Cindy

Abstract excerpt

Both the passage of time and external distraction make it difficult to keep attention on the task at hand. We tested the hypothesis that time-on-task and external distraction pose independent challenges to attention and that the brain's cholinergic system selectively modulates our ability to resist distraction. Participants with a polymorphism limiting cholinergic capacity (Ile89Val variant [rs1013940] of the...

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Identifiers

PMID: 24666128
DOI: 10.1162/jocn_a_00607
PMCID: PMC4445375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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