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Rescuing low frequency variants within intra-host viral populations directly from Oxford Nanopore sequencing data

14 Mar 2022

Abstract excerpt

Infectious disease monitoring on Oxford Nanopore Technologies (ONT) platforms offers rapid turnaround times and low cost. Tracking low frequency intra-host variants provides important insights with respect to elucidating within-host viral population dynamics and transmission. However, given the higher error rate of ONT, accurate identification of intra-host variants with low allele frequencies remains an open...

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PMID: 35288552
DOI: 10.1038/s41467-022-28852-1

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