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Article

Computational reconstruction of Bole1a, a representative synthetic hepatitis C virus subtype 1a genome.

Journal of virology - 1 May 2012

Munshaw Supriya, Bailey Justin R, Liu Lin, Osburn William O, Burke Kelly P, Cox Andrea L, Ray Stuart C

Abstract excerpt

Hepatitis C virus (HCV) research is hampered by the use of arbitrary representative isolates in cell culture and immunology. The most replicative isolate in vitro is a subtype 2a virus (JFH-1); however, genotype 1 is more prevalent worldwide and represents about 70% of infections in the United States, and genotypes differ from one another by 31% to 33% at the nucleotide level. For phylogenetic and immunologic...

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Source

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Identifiers

PMID: 22438535
DOI: 10.1128/JVI.05959-11
PMCID: PMC3347276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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