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Article

A hepatitis B virus (HBV) sequence variation graph improves alignment and sample-specific consensus sequence construction.

PloS one - 1 Jan 2024

Duchen Dylan, Clipman Steven J, Vergara Candelaria, Thio Chloe L, Thomas David L, Duggal Priya, Wojcik Genevieve L

Abstract excerpt

Nearly 300 million individuals live with chronic hepatitis B virus (HBV) infection (CHB), for which no curative therapy is available. As viral diversity is associated with pathogenesis and immunological control of infection, improved methods to characterize this diversity could aid drug development efforts. Conventionally, viral sequencing data are mapped/aligned to a reference genome, and only the aligned...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38669259
DOI: 10.1371/journal.pone.0301069
PMCID: PMC11051683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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