Article
Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Oct 2008
Frodl Thomas, Zill Peter, Baghai Thomas, Schüle Cornelius, Rupprecht Rainer, Zetzsche Thomas, Bondy Brigitta, Reiser Maximilian, Möller Hans-Jürgen, Meisenzahl Eva M
Abstract excerpt
Substantial evidence supports a role for dysfunction of the serotonin transporter (5-HTT) in the pathogenesis of major depression. The polymorphism of the serotonin transporter gene (5-HTTLPR) was found to be associated with reduced hippocampal volume in major depression. However, the original diallelic polymorphism was criticized, because the L-allele can be subtyped into La and Lg alleles, the latter of which...
Topics
- Adult
- Alleles
- Case-Control Studies
- Depressive Disorder, Major
- Female
- Genotype
- Humans
- Magnetic Resonance Imaging
- Male
- Nerve Fibers, Myelinated
- Nerve Fibers, Unmyelinated
- Organ Size