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Article

Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Oct 2008

Frodl Thomas, Zill Peter, Baghai Thomas, Schüle Cornelius, Rupprecht Rainer, Zetzsche Thomas, Bondy Brigitta, Reiser Maximilian, Möller Hans-Jürgen, Meisenzahl Eva M

Abstract excerpt

Substantial evidence supports a role for dysfunction of the serotonin transporter (5-HTT) in the pathogenesis of major depression. The polymorphism of the serotonin transporter gene (5-HTTLPR) was found to be associated with reduced hippocampal volume in major depression. However, the original diallelic polymorphism was criticized, because the L-allele can be subtyped into La and Lg alleles, the latter of which...

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PMID: 18286634
DOI: 10.1002/ajmg.b.30680

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HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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