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Article

Reorganization of corticostriatal circuits in healthy G2019S LRRK2 carriers.

Neurology - 27 Jan 2015

Helmich Rick C, Thaler Avner, van Nuenen Bart F L, Gurevich Tanya, Mirelman Anat, Marder Karen S, Bressman Susan, Orr-Urtreger Avi, Giladi Nir, Bloem Bastiaan R, Toni Ivan

Abstract excerpt

OBJECTIVE: We investigated system-level corticostriatal changes in a human model of premotor Parkinson disease (PD), i.e., healthy carriers of the G2019S LRRK2 mutation that is associated with a markedly increased, age-dependent risk of developing PD. METHODS: We compared 37 asymptomatic LRRK2 G2...

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Identifiers

PMID: 25540317
DOI: 10.1212/WNL.0000000000001189
PMCID: PMC4336002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25540317-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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