Article
Abnormal premotor-motor interaction in heterozygous Parkin- and Pink1 mutation carriers.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology - 1 Jan 2017
Weissbach Anne, Bäumer Tobias, Pramstaller Peter P, Brüggemann Norbert, Tadic Vera, Chen Robert, Klein Christine, Münchau Alexander
Abstract excerpt
OBJECTIVES: Mutations in the Parkin and PINK1 gene account for the majority of autosomal recessive early-onset Parkinson cases. There is increasing evidence that clinically asymptomatic subjects with single heterozygous mutations have a latent nigrostriatal dopaminergic deficit and could be taken as in vivo model of pre-symptomatic phase of Parkinsonism. METHODS: We charted premotor-motor excitability changes as...
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