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Article

Interactions between the C-terminus of Kv1.5 and Kvβ regulate pyridine nucleotide-dependent changes in channel gating.

Pflugers Archiv : European journal of physiology - 1 Jun 2012

Tipparaju Srinivas M, Li Xiao-Ping, Kilfoil Peter J, Xue Bin, Uversky Vladimir N, Bhatnagar Aruni, Barski Oleg A

Abstract excerpt

Voltage-gated potassium (Kv) channels are tetrameric assemblies of transmembrane Kv proteins with cytosolic N- and C-termini. The N-terminal domain of Kv1 proteins binds to β-subunits, but the role of the C-terminus is less clear. Therefore, we studied the role of the C-terminus in regulating Kv1.5 channel and its interactions with Kvβ-subunits. When expressed in COS-7 cells, deletion of the C-terminal domain of...

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PMID: 22426702
DOI: 10.1007/s00424-012-1093-z
PMCID: PMC3367765

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Source receipt: pubmed, retrieved 7 Sept 2026.

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