Article
Mutations in the Kv beta 2 binding site for NADPH and their effects on Kv1.4.
The Journal of biological chemistry - 5 Jan 2001
Peri R, Wible B A, Brown A M
Abstract excerpt
Kv beta 2 enhances the rate of inactivation and level of expression of Kv1.4 currents. The crystal structure of Kv beta 2 binds NADP(+), and it has been suggested that Kv beta 2 is an oxidoreductase enzyme (). To investigate how this function might relate to channel modulation, we made point mutations in Kv beta 2 in either the NADPH docking or putative catalytic sites. Using the yeast two-hybrid system, we found...
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