Article
Separable effects of human Kvbeta1.2 N- and C-termini on inactivation and expression of human Kv1.4.
The Journal of physiology - 15 Oct 1998
Accili E A, Kuryshev Y A, Wible B A, Brown A M
Abstract excerpt
1. The Kvbeta subunits of voltage-gated K+ channels alter the functional expression and gating of non- or slowly inactivating Kvalpha1 subunits via two separate domains. To determine how Kvbeta subunits modulate a rapidly inactivating Kvalpha1 subunit, we did two-microelectrode voltage clamp expe...
Topics
- Animals
- Biotransformation
- Electric Stimulation
- Electrophysiology
- Humans
- Ion Channel Gating
- Kinetics
- Kv1.2 Potassium Channel
- Kv1.4 Potassium Channel
- Membrane Potentials
- Mutation
- Oocytes
