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Article

Catalytic mechanism and substrate specificity of the beta-subunit of the voltage-gated potassium channel.

Biochemistry - 26 Aug 2008

Tipparaju Srinivas M, Barski Oleg A, Srivastava Sanjay, Bhatnagar Aruni

Abstract excerpt

The beta-subunits of voltage-gated potassium (Kv) channels are members of the aldo-keto reductase (AKR) superfamily. These proteins regulate inactivation and membrane localization of Kv1 and Kv4 channels. The Kvbeta proteins bind to pyridine nucleotides with high affinity; however, their catalytic properties remain unclear. Here we report that recombinant rat Kvbeta2 catalyzes the reduction of a wide range of...

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Identifiers

PMID: 18672894
DOI: 10.1021/bi800301b
PMCID: PMC2603305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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