Article
Cardiac Na+ current regulation by pyridine nucleotides.
Circulation research - 9 Oct 2009
Liu Man, Sanyal Shamarendra, Gao Ge, Gurung Iman S, Zhu Xiaodong, Gaconnet Georgia, Kerchner Laurie J, Shang Lijuan L, Huang Christopher L-H, Grace Andrew, London Barry, Dudley Samuel C
Abstract excerpt
RATIONALE: Mutations in glycerol-3-phosphate dehydrogenase 1-like (GPD1-L) protein reduce cardiac Na+ current (I(Na)) and cause Brugada Syndrome (BrS). GPD1-L has >80% amino acid homology with glycerol-3-phosphate dehydrogenase, which is involved in NAD-dependent energy metabolism. OBJECTIVE: Therefore, we tested whether NAD(H) could regulate human cardiac sodium channels (Na(v)1.5). METHODS AND RESULTS: HEK293...
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