Article
Alteration and restoration of K+ channel function by deletions at the N- and C-termini.
Neuron - 1 Oct 1990
VanDongen A M, Frech G C, Drewe J A, Joho R H, Brown A M
Abstract excerpt
Voltage-dependent ion channels are thought to consist of a highly conserved repeated core of six transmembrane segments, flanked by more variable cytoplasmic domains. Significant functional differences exist among related types of K+ channels. These differences have been attributed to the variable domains, most prominently the N- and C-termini. We have therefore investigated the functional importance of both...
Topics
- Animals
- Brain
- Chromosome Deletion
- Electrophysiology
- Ion Channel Gating
- Kinetics
- Mutation
- Potassium Channels
- Rats